Publications

Murch WS, Chu SW, Clark L Measuring the slot machine zone with attentional dual tasks and respiratory sinus arrhythmia. Psychology of Addictive Behaviors, 2017, 31: 375-384.

Limbrick-Oldfield E, Mick I, Cocks RE, McGonigle J, Sharman S, Goldstone AP, Stokes PRA, Waldman A, Erritzoe D, Bowden-Jones H, Nutt D, Lingford-Hughes A, & Clark, L. Neural substrates of cue reactivity and craving in Gambling Disorder. Translational Psychiatry, 2017, 7(1):e992.

Tobias-Webb J, Limbrick-Oldfield E, Gillan C, Moore J, Aitken MRF, Clark L. “Let me take the wheel”: illusory control and sense of agency. Quarterly Journal of Experimental Psychology, 2017, 70: 1732-1746.

Vlaev I, Clark L, Muller U, Robbins TW, Crockett MJ. Serotonin enhances the impact of health information on food choice. Cognitive Affective & Behavioral Neuroscience, 2017, 17: 543-553.

Wu Y, Blue PR, Clark L. Winning a competition predicts dishonest behavior (Commentary). Frontiers in Neuroscience, 2017, 11:417.

Wu Y, van Dijk E, Aitken MRF, Clark L. On the counterfactual nature of near-misses: an experimental study. Journal of Behavioral Decision Making, 2017, in press.

Wu Y, Eisenegger C, Zilioli S, Watson NV, Clark L. Comparison of clear and narrow outcomes on testosterone levels in social competition. Hormones and Behavior, 2017, 92: 51-56.

Naef M, Müller U, Linssen A, Clark L, Robbins TW, Eisenegger C. Effects of dopamine D2/D3 receptor antagonism on human planning and spatial working memory. Translational Psychiatry, 2017, 7: e1107.

Yücel M, Carter A, Allen A, Balliene B, Clark L, Dowling N, Gainsbury S, Goudriaan A, Grant J, Hayes A, Hodgins D, van Holst R, Lattimore R, Livingstone C, Lorenzetti V, Lubman D, Murawski C, Parkes L, Petry N, Room R, Singh B, Thomas A, Townshend P, Youssef G, Hall W. The role for neuroscience in gambling policy and treatment: An interdisciplinary perspective. The Lancet Psychiatry, 2017, 4: 501-506.

Clark L. Decision-making in gambling disorder: understanding behavioural addictions. In: Dreher JC & Tremblay L. Decision Neuroscience: an Integrative Perspective. Elsevier, 2016.

Clark L, Robbins TW. Reply to: Systematic overestimation of reflection impulsivity on the Information Sampling Task. Biological Psychiatry 2016, 2017, 82: e31.

Mick I, Ramos A, Myers J, Stokes PR, Chandrasekera S, Erritzoe D, Mendez M, Gunn R, Rabiner I, Searle G, Galduróz JC, Waldman A, Bowden-Jones H, Clark L, Nutt D, Lingford-Hughes A. Evidence for GABA-A receptor dysregulation in gambling disorder: correlation with impulsivity. Addiction Biology 2016, in press.

Sescousse G, Janssen LK, Hashemi MM, Timmer MHM, Geurts DEM, ter Huurne NP, Clark L, Cools R. Amplified striatal responses to near-miss outcomes in pathological gamblers. Neuropsychopharmacology, 2016, 41: 2614-23. doi:10.1038/npp.2016.43

Wu Y, Liu J, Qu L, Eisenegger C, Clark L, Zhou X. Single dose testosterone administration reduces loss chasing in healthy females. Psychoneuroendocrinology 2016, 71: 54-57.

Sharman S, Dreyer J, Clark L, & Bowden-Jones H (2016). Down and out in London: addictive behaviours in homelessness. Journal of Behavioural Addictions, 2016, 5: 319-326.

Studer B, Scheibehenne B, Clark L. Psychophysiological arousal and inter- and intra-individual differences in risk-sensitive decision-making. Psychophysiology, 2016, 53: 940-950. doi: 10.1111/psyp.12627

Sharman S, Clark L. Mixed emotions to near-miss outcomes: a psychophysiological study with facial electromyography. Journal of Gambling Studies, 2016, 32, 823-834. DOI: 10.1007/s10899-015-9578-2

Winstanley CA, Clark L. Translational models of gambling-related decision making. In: Translational Neuropsychopharmacology, ed. Robbins TW & Sahakian BJ. Current Topics in Behavioural Neuroscience, 2016, 28:93-120.

Silveira MM, Murch WS, Clark L & Winstanley CA. Chronic atomoxetine treatment during adolescence does not influence decision-making on a rodent gambling task, but does modulate amphetamine’s effect on impulsive action in adulthood. Behavioral Pharmacology, 2016, 27, 350-363.

Brevers D, Noel X, Clark L, Zyuzin J, Park JJ, Bechara A. The impact of precommitment on risk-taking while gambling: A preliminary study. Journal of Behavioural Addictions 2016, 5: 51-58

Cocker PJ, Hosking JG, Murch WS, Clark L & Winstanley CA. Activation of dopamine D4 receptors within the anterior cingulate cortex enhances the erroneous expectation of reward on a rat slot machine task. Neuropharmacology 2016, 105: 186-195.

Segarra N, Metastasio A, Ziauddeen H, Spencer J, Reinders NR, Dudas RB, Arrondo G, Robbins TW, Clark L, Fletcher PC, Murray GK. Abnormal frontostriatal activity during unexpected reward receipt in depression and schizophrenia: relationship to anhedonia. Neuropsychopharmacology 2016, 41: 2001-2010. doi: 10.1038/npp.2015.370

Wu Y, van Dijk E, Aitken MRF, Clark L. Missed losses loom larger than missed gains: Electrodermal reactivity to decision choices and outcomes in a gambling task. Cognitive Affective and Behavioral Neuroscience, 2016, 16: 353-61 .

Devos G, Clark L, Maurage P, Billieux J. Reduced inhibitory control predicts persistence in laboratory slot machine gambling. International Gambling Studies, 2015, 15: 408-421

Murch WS, Clark L. Games on the brain: Neural substrates of gambling addiction. The Neuroscientist 2016, 22: 534-545. DOI: 10.1177/1073858415591474

Mick I, Myers J, Ramos AC, Stokes PR, Erritzoe D, Colasanti A, Gunn RN, Rabiner I, Searle G, Waldman A, Parkin MC, Brailsford AD, Galduroz JCF, Bowden-Jones H, Clark L, Nutt DJ, Lingford-Hughes AR. Blunted endogenous opioid release following an oral amphetamine challenge in pathological gamblers. Neuropsychopharmacology 2016, 41: 1742-50. doi: 10.1038/npp.2015.340

Clark L, Bechara A. Isolating the role of the insula in drug cravings (commentary on Abdolahi et al 2015). Addiction 2015, 110: 2004-2005.

Chu SW, Clark L. Cognitive and neurobiological aspects of problem gambling: relevance to treatment. Canadian Journal of Addiction 2015, 6: 62-71

Clark L. From impulsivity to addiction: Gambling Disorder and beyond. Psychiatric Times 2015, 32: 24-25.

Sharman S, Aitken MRF, Clark L. Dual effects of ’losses disguised as wins’ and near-misses in a slot machine game. International Gambling Studies, 2015, 15: 212-223. DOI: 10.1080/14459795.2015.1020959

Contreras-Rodríguez O, Albein-Urios N, Vilar-López R, Perales JC, Martínez-Gonzalez JM, Fernández-Serrano MJ, Lozano-Rojas O, Clark L, Verdejo-García A. Increased corticolimbic connectivity in cocaine dependence versus pathological gambling is associated with drug severity and emotion-related impulsivity. Addiction Biology, 2015 DOI: 10.1111/adb.12242.

Clark L. Commentary on Cassidy, ‘Fair Game? Producing and publishing gambling research’. International Gambling Studies, 2015, 15: 10-11. DOI: 10.1080/14459795.2014.997269

Clark L. Commentary on Billieux et al ‘Are we overpathologizing everyday life? A tenable blueprint for behavioral addiction research’ Journal of Behavioral Addictions 2015, 4, 132–134. DOI: 10.1556/2006.4.2015.014

Wu Y, van Dijk E, Clark L. Near-wins and near-losses in gambling: a behavioral and facial EMG study. Psychophysiology 2015, 52: 359-66 .

Wu Y, Clark L. Disappointment and regret enhance corrugator reactivity in a gambling task. Psychophysiology 2015, 52: 518-523.

Studer B, Limbrick-Oldfield E, Clark L. “Put your money where your mouth is!” Effects of streaks on confidence and betting in a binary choice task. Journal of Behavioral Decision Making, 2015, 28: 239-249. DOI: 10.1002/bdm.1844.

Verdejo-Garcia A, Clark L, Verdejo-Román J, Albein-Urios N, Martinez-Gonzalez JM, Gutierrez B, Soriano-Mas C. Neural substrates of cognitive flexibility in cocaine and gambling addictions. British Journal of Psychiatry, 2015, 207: 158-164. doi: 10.1192/bjp.bp.114.152223.

Landro NI, Jonassen R, Clark L, Foss Haug KB, Aker M, Bø R, Berg JP, Neumeister A, Stiles TC. Serotonin transporter polymorphisms predict response inhibition in healthy volunteers. Neuroscience Letters 2015, 584:109-12.

Hamilton KR, Littlefield AK, Anastasio NC, Cunningham KA, Fink LH, Wing VC, Mathias CW, Lane SD, Schutz C, Swann AC, Lejuez CW, Clark L, Moeller FG, Potenza MP. Rapid-Response Impulsivity: Definitions, Measurement Issues, and Clinical Implications. Personality Disorders: Theory, Research, and Treatment 2015, 6: 168-181. DOI:10.1037/per0000100

Dombrovski AY, Szanto K, Clark L, Aizenstein H, Chase HW, Reynolds CF, Siegle GJ. Corticostriatothalamic reward prediction error signals and executive control in late-life depression. Psychological Medicine 2015, 45: 1413-1424.

Robbins TW, Clark L. Behavioral addictions. Current Opinion in Neurobiology 2015, 30: 66-72.

Studer B, Manes FM, Humphreys G, Robbins TW, Clark L. Risk-sensitive decision-making in patients with posterior parietal and ventromedial prefrontal cortex injury. Cerebral Cortex, 2015, 25: 1-9.

Tobias-Webb J, Clark L. Gambling: Pathological Decision-Making. Encyclopedia of the Life Sciences (eLS) 2015, 1–8. DOI: 10.1002/9780470015902.a0025788.

Clark L. Disordered gambling: the evolving concept of behavioural addiction. Annals of the New York Academy of Science (Addiction Reviews) 2014, 1327: 46-61.

Clark L, Sharman S. Understanding the abuse liability of modern EGMs (Commentary on M. J. Dixon et al, 2014). Addiction 2014, 109: 1929-1930.

Van Holst R, Chase H, Clark L. Striatal connectivity changes following gambling wins and near-misses: associations with gambling severity. NeuroImage: Clinical, 2014, 5: 232-239.

Van Holst R, Clark L, Veltman DJ, van den Brink W, Goudriaan AE. Enhanced striatal responses during expectancy coding in alcohol dependence. Drug and Alcohol Dependence 2014: 142: 204-208.

Clark L, Studer B, Bruss J, Tranel D, Bechara A. Damage to insula abolishes cognitive distortions during simulated gambling. Proceeding of the National Academy of Sciences of the USA 2014, 111: 6098-6103.
Mick I, Myers J, Stokes PR, Erritzoe D, Colasanti A, Bowden-Jones H, Clark L, Gunn RN, Rabiner I, Searle G, Waldman A, Parkin MC, Brailsford AD, Nutt DJ, Lingford-Hughes AR. Amphetamine induced endogenous opioid release in the human brain detected with [11C]carfentanil PET: Replication in an independent cohort. International Journal of Neuropsychopharmacology 2014, 17: 2069-2074.

Sharman, Dreher J, Aitken M, Clark L, Bowden-Jones H. Rates of problematic gambling in a British homeless sample: a preliminary study. Journal of Gambling Studies 2015, 31: 525-32DOI: 10.1007/s10899-014-9444-7.

[Sharman, Aitken M, Clark L: Reply to Griffiths: the relationship between gambling and homelessness, Journal of Gambling Studies 2015, 31: 1257-9 DOI 10.1007/s10899-014-9508-8]

Eisenegger C, Naef M, Linssen A, Clark L, Gandamaneni PK, Muller U, Robbins TW. Role of dopamine D2 receptors in human reinforcement learning. Neuropsychopharmacology 2014, 39: 2366–2375.

Stankovic A, Fairchild G, Aitken MRF, Clark L. Effects of Psychosocial Stress on Psychophysiological Activity During Risky Decision-Making in Male Adolescents. International Journal of Psychophysiology 2014, 93: 22-29.

Clark L, Averbeck B, Payer D, Sescousse G, Winstanley CA, Xue G. Pathological choice: the neuroscience of gambling and gambling addiction. Journal of Neuroscience 2013, 33: 17617-17623.

Clark L, Limbrick-Oldfield EH. Disordered gambling: a behavioural addiction. Current Opinion in Neurobiology 2013, 23: 655-659.

Clark L, Liu R, McKavanagh R, Garrett A, Dunn BD, Aitken MRF. Learning from near-miss outcomes in simulated gambling. Journal of Behavioral Decision Making, 2013, 26: 442-450.

Porchet RI, Boekhoudt L, Studer B, Gandamaneni PK, Rani N, Binnamangala S, Müller U, Clark L. Opioidergic and dopaminergic manipulation of gambling tendencies: a preliminary study in male recreational gamblers. Frontiers in Behavioural Neuroscience, 2013 7: 138.

Limbrick-Oldfield EH, van Holst R, Clark L. Fronto-striatal dysregulation in drug addiction and pathological gambling: consistent inconsistencies? NeuroImage: Clinical 2013, 2: 385-393

Crockett MJ, Apergis-Schoute AM, Herrmann B, Lieberman MD, Müller U, Robbins TW, Clark L. Serotonin modulates neural responses to fairness and retaliation in humans. Journal of Neuroscience 2013, 33: 3505-3513.

Huddy VC, Clark L, Harrison I, Ron MA, Moutoussis M, Barnes TR, Joyce EM. Reflection impulsivity and response inhibition in first-episode psychosis: relationship to cannabis use. Psychological Medicine 2013, 43: 2097-2107.

Crockett MJ, Braams BR, Clark L, Tobler PN, Robbins TW, Kalenscher T. Restricting temptations: neural mechanisms of precommitment. Neuron 2013, 79: 391-401.

Dombrovski AY, Szanto K, Clark L, Reynolds CF, Siegel G. Reward signals in late-life depression and attempted suicide. JAMA Psychiatry 2013, 70: 1020-1030.

Clark L, Stokes PR, Wu K, Michalczuk R, Benecke A, Watson BJ, Egerton A, Piccini P, Nutt DJ, Bowden-Jones H, Lingford-Hughes AR. Striatal dopamine D2/D3 receptor binding in pathological gambling is correlated with mood-related impulsivity. NeuroImage, 2012, 63: 40-46.

Clark L, Li R, Wright CM, Rome F, Fairchild G, Dunn BD, Aitken MRF. Risk-avoidant decision-making induced by threat of electric shock. Psychophysiology, 2012, 49: 1436-1443.

Clark L, Crooks B, Clarke R, Aitken MRF, Dunn BD. Physiological responses to near-miss outcomes and personal control during simulated gambling. Journal of Gambling Studies, 2012, 28: 123-137.

Studer B, Apergis-Schoute A, Robbins TW, Clark L. What are the odds? The neural correlates of active choice during gambling. Frontiers in Neuroscience (Decision Neuroscience) 2012, 6: 46.

Billieux J, van der Linden M, Khazaal Y, Zullino D, Clark L. Trait gambling cognitions predict near-miss experiences and persistence in laboratory slot machine gambling. British Journal of Psychology 2012, 103: 412-427.

Dunn BD, Evans D, Makarova D, White J, Clark L. Gut feelings and the reaction to perceived inequity: The interplay between bodily responses, regulation and perception shapes the rejection of unfair offers on the Ultimatum Game. Cognitive, Affective and Behavioral Neuroscience 2012, 12: 419-429. [Psychonomic Society Prize for best paper in CABN, 2012]

Chase H, Clark L. Gambling severity predicts midbrain response to near-miss outcomes. Journal of Neuroscience 2010, 30: 6180-6187.

Clark L, Lawrence AJ, Astley-Jones F, Gray N. Gambling near-misses enhance motivation to gamble and recruit win-related brain circuitry. Neuron 2009, 61: 481-490.